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Key expertise

Lipids

In the pharmaceutical industry, lipids are core excipients in the development of drug delivery systems. Lipids can be used in most dosage forms as support vehicles, solubilizers, permeation enhancers, stabilizers, transfection agents and release rate modifiers.
Li
Lipids

Your global partner for the manufacturing of synthetic lipids

Such lipids are particularly relevant for the development of optimized RNA / DNA delivery systems, and allow a better bioavailability of drugs or vectorized vaccines. 
Our commitment is to support our customers in reaching the highest requirements in terms of ingredients performances, selectivity and quality. Our services allow to fine-tune the chemical structure, create opportunities for IP generation, and deliver the products at all stages of the product life cycle.

SEQENS answers customers’ needs for Custom Lipids, which are typically used in drug delivery systems to improve the bioavailability of drugs :

  • Lipid Nanoparticles for mRNA/siRNA/DNA
  • Transfection Vectors for Gene Therapies
  • Immunotherapies (CAR-T-Cells)
  • Lipid prodrugs
  • Liposome Vectorization for Oncology, Pain…
  • Lipid-Polymer Hybrid Nanoparticles
  • Cosmetic Lipids

2 expert R&D centers for drug delivery lipids

BOSTON’LAB: Small Molecules, Lipids & Polymers

  • 1,000 sqm lab-floor
  • 5 kilo-labs
  • 1 pilot plant
  • 30 scientists with > 50% PHD

SEQENS’LAB: Small Molecules & Lipids

  • 4 kilo-labs
  • 2 cGMP pilot plants with 11 multipurpose reactors (total capacity of 12 m3)
  • 110 scientists with > 50% PHD

Our custom lipids offer

With a recognized 10 years-experience in Custom Lipids development and manufacturing, SEQENS has the ability to serve customers with:
  • Neutral Lipids
  • PEG-lipids
  • Cationic/Ionizable lipids
  • Phospholipids
  • Cholesterol derivatives
  • Intermediates
Seqens has a wide range of expertise in synthetic Lipid process development and scale-up, benefiting from existing assets:
1
GMP CUSTOM LIPID CDMO

Capabilities in US and EU
Support preclinical & clinical studies
From grams to tens of kilograms

2
TOLLING CAPABILITIES

For commercial-scale GMP Lipid synthesis
Up to multi-tons scale

3
CUSTOM LIPID INTERMEDIATES

Leveraging Seqens worldwide non-GMP Assets
Up to multi-tons scale

Our technologies’ offer for custom lipids development and manufacturing

Available at Lab scale, GMP kg-Lab scale and GMP commercial supply

Synthesis

  • Non-GMP reactors for lipid intermediates
  • GMP reactors for GMP lipids

Purification

  • Flash Chromatography
  • High Pressure Chromatography (under upgrade for GMP scale-up)
  • Solvent evaporation
  • Crystallization and drying

Analytics

  • Best-in-class analytical tools (including Thin-layer Chromatography/MS)
  • Stability studies
  • Process safety studies

 

Discover other R&D services

Ap

Plateforme Analytique

Analytical Platform

Seqens provides GMP testing on Active Pharmaceutical Ingredients (API) and excipients. We have an extensive team focused on the development and clinical phase appropriate validation of sensitive and specific analytical methods

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Bi

Bio
disponibilité

Bioavailability

40% of drugs fail in preclinical trials due to bioavailability issues. Seqens has a strong expertise to support you regarding bioavailability challenges.

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Bi

Biocatalyse

Biocatalysis

Biocatalysis is the usage of enzymes as catalysts of chemical reactions. Learn more about Seqens extensive expertise.

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Sy

Biologie Synthétique

Synthetic Biology for bioinspired and sustainable innovations

Part of Seqens group, Alganelle is an innovative biotechnology company at the cutting edge of synthetic biology and metabolic engineering.

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Ca

Caracté
risation

Characterization of APIs

Physical Characterization Testing Capabilities includes a full set of advanced technologies

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Im

Immuno
conjugués

Drug Conjugates

The field of drug conjugates is emerging, with the possibility to achieve 2 functions with one (bifunctional) compound, usually allowing targeted therapies or improved bioavailability properties.

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Mu

Multipurpose Flow

Multipurpose Flow Chemistry

In flow chemistry, a chemical reaction is run in a continuously flowing stream rather than in batch production, leading to many key advantages.

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P

Polymers

Polymers

Seqens strongly believes in the potential of new cutting-edge technologies to improve the use and efficiency of existing APIs. To support its customers, Seqens offers a range of drug delivery polymers.

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So

Solid State

Solid State characterization

The need to investigate the solid state properties of APIs has become important in the pharmaceutical development industry. Physical properties can vary widely between batches, leading to batch-to-batch variability.

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