Multicatalysis – Pushing the boundaries beyond multi-disciplinarities
The concept of multi-catalysis is an emerging field targeting the development of new efficient catalytic systems combining multi-step synthesis in new ‘one-pot’ transformations or in multi-catalytic sequences.
In this article, we will review the main classification of multi-catalysis strategies and illustrating some case-studies which combine different catalysis fields leading to some remarkable opportunities to outcompete classical approaches. Despite major challenges that need to be addressed with respect to compatibility issues and catalyst reactivity ordering, the implementation of such processes enables to strengthen the collaboration across many disciplines enhancing interdisciplinary competences.
Juliette Martin, Scientific Communication Manager at SEQENS
Facing a highly competitive global market with increasing awareness on environmental issues, chemical production is making its way toward a paradigm shift to more efficient, more environmentally friendly, and more versatile manufacturing processes. In this white paper, we wish to review some of the key advanced tools available to process chemists for addressing the challenges in process intensification.
During this webinar, we present the specific challenges encountered by Biotech companies when developing New Chemical Entities from Discovery phase to Early Clinical phases. A case study is presented on an API presenting a low water solubility and at the same time a low solubility in lipophilic solvents.
Discover in the latest Organic Letters issue, how SEQENS in collaboration with Géraldine Masson, have developed a more greener approach for the decarboxylative borylation, leading efficiently to a- and b-amino-boronamides, an important class of compounds in medicinal chemistry.
This paper presents the different strategies considered to enhance pharmaceutical drugs bioavailability.
A special focus is made on the need
to understand, at early stage, the behaviour and the characteristics of these compounds, especially physical, chemical and biological