Peptides in the era of biotech

Several emerging strategies leveraged by automated labs, aim to improve discovery, efficiency and reliability in designing chemical routes.

High throughput screening (HTS) and experimentation (HTE) are techniques which allow the execution of large numbers of experiments to be conducted in parallel while requiring less effort per experiment when compared to conventional means of experimentation. A reiterative process of design, execution, data analysis, and hit identification enables rapid exploration of conditions for reaction discovery and optimization.

Amphotericin B is a well-known and mature antifungal drug which is used in the treatment of bloodborne parasitic and fungal infections. However, its use has been limited by dose-dependent kidney toxicity. Oral formulation approaches have focused on the dual problem of solubility and permeability of Amphotericin B (AmphB), which is poorly water soluble, amphoteric and has extremely low oral bioavailability. In this article, we would like to highlight some of the key features in the history of AmphB and the attempts to reduce its toxicity through formulation strategies.