Cosmetics / Pharmaceutical / Specialties
Vitamin E TPGS
Vitamin E TPGS is a surfactant which can be used as emulsifier, drug solubilizer, absorption enhancer, and as a vehicle for lipid-based, drug delivery formulations.
Technical characteristics
Vitamin E TPGSCAS N° 9002-96-4
Water soluble derivative of Vitamin E
Physical form: waxy solid with low melting-point: 36 – 42°C
Multirole Excipient
Solubilizer of poorly soluble drug substance
Manufactured under GMP – FDA site approved
Molecular Weight: ∼ 1513
Color: White to light tan
Vitamin E TPGS is a surfactant which can be used as emulsifier, drug solubilizer, absorption enhancer, and as a vehicle for lipid-based, drug delivery formulations.
PROPERTIES OF VITAMIN E TPGS
- Improving Drug Bioavailability Surfactant properties enhance solubilization of poorly water soluble drugs
-Stabilization of amorphous drug
-Enhances drug permeability by P-glycoprotein efflux inhibition.
-Emulsion vehicle
- Functional Ingredient in self-emulsifying formulations
- Thermal binder in melt granulation/extrusion processing
- Reducing drug sensitivity on skin or tissues
- Carrier for wound care and treatment
- Water soluble source of Vitamin E
APPLICATION FIELD OF VITAMIN E TPGS
Due to its properties, Vitamin E TPGS is used for various applications:
- Pharmaceutical
- Nutraceuticals
- Food & Beverage
- Cosmetic & Personal Care
- Animal Nutrition
Our location
CDMO Lahr
Germany
Address
Raiffeisenstraße 4
77933 Lahr
77933 Lahr
Business Line
Custom Manufacturing, APIs & Intermediates
Phone
49 7821 585 0
Market
Pharmaceutical
Email
info-lahr@seqens.com
More information
Surface: 48, 000 m²
Lab surface: 700 m²
Capabilities:
- Total reactor capacity: 92 m³
- Reaction vessels: 1 to 6 300 L; temperature -80°C to +250 °C
- Multi-purpose state of the art cGMP facilty: 4 independent, vertical integrated production trains 800 L train, 2 x 3 000 L trains plus 1 x 3 000 L low temperature hydrogenation reactor and 6 000 L train
- Classic two-floor layout Facility: 20 vessels with capacity between 800 and 6 000 L (glaslined and SS)
- Autoclaves (operational range up to 100 bar)
- Kilo-Lab: 3 reactors: 25 / 100 / 250 L
Flagship technologies:
- Hydrogenation
- Reductive amination
- Organometallic reactions
- Protected AADs (Aminoacid derivatives)
- Carbonylation & Hydroformylation
- Pressure aminolysis, other reactions under pressure
- Cryogenic chemistry
- Enantiopure synthesis
- Cyanation high volumes (NaCN) C-C coupling
- Reductions
- Halogenation
Last inspections:
- FDA 2018
- German Pharma Authority 2018
Certifications:
- GMP
- ISO 9001
- ISO 50001
Number of scientists: 25