Di-n-Butyl Ether

WHAT IS DI-N-BUTYL ETHER?

Di-n-Butyl ether is a speciality solvent that is finding increasing use as a replacement for THF in Grignard, Wittig and other organo-metallic reactions and is used in the production of CD-R.

Applications

Di-n-Butyl Ether is a powerful and cost effective solvent for Grignard reactions, particularly those with β-hydrogens increasing the yield of addition products.

It is a good solvent for oils and fats and some natural and synthetic resins. Its properties make it robust for use with either organic acids or alkalis. It is used in the manufacturing process of a range of pharmaceutical API’s such Procarbazine and Cefaclor. It is also used in the manufacture of agrochemicals such as Cyhexatin. CD-R manufacture uses Di-n-butyl Ether as the principle solvent for the application of the coating. It has over 23,000 references in SciFinder and is the key solvent in over 300 patents. It is used widely in Alkyl Lithium, Wittig and other organo-metallic reactions

Di-n-butyl ether is an excellent choice of solvent both commercially and technically for a wide range of synthetic reactions and processes where its low water and peroxide content and high boiling point allows for higher process temperatures. Its flash point is higher than other conventional solvents adding to its safety aspects, and it is a much easier solvent to recover after use than THF, making the process more economic.