Pharmaceutical Solutions
A leader in Pharmaceutical solutions
Mastering a wide range of technologies, Seqens provide their clients with custom manufacturing services as well as a broad portfolio of Active Pharmaceutical Ingredients (APIs) & intermediates. Seqens offer technical excellence, continuous improvement plans and innovative tailor made solutions from a network of 4 R&D centers serving the Pharmaceutical market, 4 pilot units and 12 cGMP sites, including 6 cGMP multi-purposes manufacturing sites.
Seqens ensure seamless in-house process development, scale-up and manufacturing from early clinical phases to the commercial stage, in order to accompany fast track market access for their clients. Throughout its diversified network, Seqens provide their customers with secured supply chain, based on vertical integration from raw materials to APIs manufacturing.
- Seqens is a leading provider of organic chemistry solutions for the pharmaceutical market
- We support the pharmaceutical companies, from biotechs to large pharmas, from the pre-clinical to the commercial phases
- We have 250 chemical engineers and scientists and 120 PhDs
- We leverage our continuum of technologies, from R&D to mass API production
- Additionally we have a portfolio of 70 on-the-shelf APIs that we provide to our clients, with the required regulatory support for marketing in more than 100 countries
- We run integrated facilities that manufacture a number of input products for the life science industry
Our locations
Shanghai
China200060 Shanghai
Ecully
France69134 Ecully
- Seqens Group headquarter
- Essential Drug Substances headquarter
- Solvent & Phenol Specialties headquarter
- Acid & Derivatives headquarter
Boston'Lab (Devens)
United StatesMA 01434 Devens
Facility Highlights:
- 10,000 sq. ft. facility with 6 laboratories that house 28 hoods.
- 30 person staff, ¾ PhD’s
- 5 kilo lab hoods
Equipment:
- Glassware from ml to 100 liter jacketed glass vessels
- 20 and 50 liter rotovaps
- Various filtration equipment
- Temperature ranges -78 – 240°C
- Thin film evaporation
- Flash chromatography
- Prep chromatography
- Micronization
- High pressure par reactors
Porcheville (Seqens'Lab)
France78440 Porcheville
Surface: 40, 000 m²
Lab surface: 2, 000 m²
Capabilities:
- 6 kilo-labs
- 2 cGMP pilot plants with 11 multipurpose reactors from 100 L to 2, 800 L (total capacity of 12 m³)
- Temperature range: -15/+150°C (hastelloy reactor: -80/+200°C)
- 3 finishing rooms (agitated filter dryers, filters, dryers, milling and sieving equipments)
Flagship technologies:
- Crystallization expertise and technologiesd(salt, co-crystal and polymorph screenings, process development)
- Process Safety expertise and tecnologies
- Flow chemistry for fine chemicals
- Potent API process development
- Genotoxic Impurities
- Issue Management
- Generic A.P.I Solid state expertise
Last inspection: ANSM October 2018
Certification: GMP
Number of scientists: 110
Other: Ecosystem Pharma with integrated services
Nîmes Protéus by Seqens
France30000 Nîmes
Surface: 1, 000 m²
Lab surface: 500 m²
Capacities:
- 1 kilo-lab in fermentation (80 L total capacity)
- Robotic platform for highthroughput screening (HTS)
- Analytical platform for chromatography (GC, GC-MS, U-HPLC)
Flagship technologies:
- Protein engineering
- Microbiology aerobic & anaerobic
- Syngas fermentation
- Enzymes & strains fermentation
- Biochemistry
- Biocatalysis
- Design of experiments (DoE)
- Data mining
Number of scientists: 19
EcoVadis CSR Rating: Silver Certification
CDMO Aramon
France30390 Aramon
Capabilities:
- 100 m³ of GMP reactors
- 50 L – 10 000 L vessels
Flagship technologies:
- Organometallic chemistry
- Large-scale hydrogenation
- Diborane chemistry
- Ethylene oxide reactions
- Biocatalysis platform
- Polymer production (PLGA)
- Enzymatic synthesis Skraup reactions
EcoVadis CSR Rating: Silver certification
Last inspections:
- FDA 2018
- ANSM 2021
CDMO Bourgoin-Jallieu
France38300 Bourgoin-Jallieu
Flagship technologies: Distillation
EcoVadis CSR Rating: Gold Certification
CDMO Lahr
Germany77933 Lahr
Surface: 48, 000 m²
Lab surface: 700 m²
Capabilities:
- Total reactor capacity: 92 m³
- Reaction vessels: 1 to 6 300 L; temperature -80°C to +250 °C
- Multi-purpose state of the art cGMP facilty: 4 independent, vertical integrated production trains 800 L train, 2 x 3 000 L trains plus 1 x 3 000 L low temperature hydrogenation reactor and 6 000 L train
- Classic two-floor layout Facility: 20 vessels with capacity between 800 and 6 000 L (glaslined and SS)
- Autoclaves (operational range up to 100 bar)
- Kilo-Lab: 3 reactors: 25 / 100 / 250 L
Flagship technologies:
- Hydrogenation
- Reductive amination
- Organometallic reactions
- Protected AADs (Aminoacid derivatives)
- Carbonylation & Hydroformylation
- Pressure aminolysis, other reactions under pressure
- Cryogenic chemistry
- Enantiopure synthesis
- Cyanation high volumes (NaCN) C-C coupling
- Reductions
- Halogenation
Last inspections:
- FDA 2018
- German Pharma Authority 2018
Certifications:
- GMP
- ISO 9001
- ISO 50001
Number of scientists: 25
EcoVadis CSR Rating: Gold Certification
CDMO Limay
France78520 Limay
Capabilities:
- 70 m³ of GMP reactors
- 100 L – 8 000 L vessels
Flagship technologies:
- Optical resolution
- Enzymatic hydrolysis
- Enantioselective reduction
- Low-temperature reactions (-80 °C)
- Specific reduction
- Hydrogenation (40 bar)
- Organomagnesium compounds
- Thin-layer distillation
EcoVadis CSR Rating: Gold Certification 2019
Last inspections:
- FDA 2018
- ANSM 2019
CDMO Turku
Finland20210 Turku
Surface: 11, 678 m²
Lab surface: 695 m²
Capabilities:
- 4 separate modules
- 72 m³ reactor capacity-
- 250 L – 6300 L vessels
Flagship technologies:
- Biphosphonate chemistry
- Hydrogenation (20 bar)
- Chlorination
- Cyanation (NaCN) in separate installations
- Reduction with complex hydrids
- Biocatalysis
- Manufacturing of parenteral/injectable APIs
- Separate production modules and final processing facilities
Last inspections:
- FDA 2019
- PMDA 2018
- FIMEA 2018
Number of scientists: 16
EcoVadis CSR Rating: Silver Certification
CDMO Villeneuve-la-Garenne
France92390 Villeneuve-la-Garenne
Capabilities:
- 65 m³ of reactors
- 100 L – 2 500 L vessels
EcoVadis CSR Rating: Gold Certification
Last inspections:
- ANSM 2019
- ANVISA (Brasil) 2018
- FDA 2016
Essential Drug Substances Bangpoo
Thailand10280 Samut Prakan
Surface: 24, 000 m²
Lab surface: 100 m²
Capabilities: 3.5 KT ASA
Flagship technologies:
- Continuous Acetylsalicylic
- Acid Production Recycled
- Salicyclic Acid (Industrial-grade)
Last inspections:
- USFDA, March 2018
- TFDA, May 2018
Certifications:
- ISO 9001
- ISO 14001
- OHSAS 18001
- EcoVadis CSR Rating: Gold Certification
Number of scientists: 11
Essential Drug Substances Roussillon
France38556 Roussillon
Capabilities:
- 20 kt Salicylic ACid
- 6 kt Methyl Salicilate
Last inspections:
- ANSM, February 2018
- FDA, June 2016
- ISO, March 2018
Certifications:
- cGMP
- ISO 9001
- ISO 14001
- OHSAS 18001
- ISO 22000
- Kascher
- Halal
- EcoVadis CSR Rating: Platinium certification
Essential Drug Substances Saint-Fons
France69190 Saint-Fons
Capabilities: 6 KT of Acetylsalicylic Acid
Certifications:
- cGMP
- ISO 9001
- ISO 14001
- OHSAS 18001
EcoVadis CSR Rating: Platinum Certification
Essential Drug Substances Wuxi
China214185 Wuxi
Surface: 38, 619 m²
Lab surface: 560 m²
Capabilities:
- 8 KT of Paracetamol
- 4.5 KT of DC range
Flagship technologies:
- Acetylation reaction
- Refining, granulation
Last inspections:
- ANSM, January 2018
- NMPA ,August 2018
Certifications:
- EU GMP
- ISO 140001
- OHSAS 18001
- EcoVadis CSR Rating: Silver Certification
Essential Drug Substances Yangzi
China225404 Taizhou
Surface: 50 000 m²
Lab surface: 750 m²
Capabilities: 35 KT PAP
Flagship technologies: Catalytical hydrogenation
Last inspection: June 2017
Certifications:
- ISO 9001
- ISO 14001
- OHSAS 18001
- Certificate of GMP issued by Norwegian Medicines Agency for PAP workshop 2 only
In Vitro Diagnostic Limoges
France87068 Limoges
Capabilities: 5, 050 L of reactors (100 L to 2, 000 )
Flagship technologies: Blood fractionation for In Vitro Diagnostic
Certifications:
- ISO 9001
- ISO 14001
Number of scientists: 2
Solvent & Phenol Specialties Roussillon
France38556 Roussillon
Surface : 160 000 m²
Capabilities:
- 185 kT Phenol
- 70 kT Isopropanol
- 27 kT Acétate Isopropyle
- 5 kT DIPE
Certifications:
- ISO 9001
- ISO 14001
- ISO 50001
- OSHAS 18001
EcoVadis CSR Rating Platinum medal
CDMO Newburyport
United StatesMA 01950 Newburyport
Custom Manufacturing: don.laferle@seqens.com
Proprietary API: laurent.alexandre@seqens.com
Essential Drug Substances Robbinsville
United StatesNJ 08691 Robbinsville
Massy
France91300 Massy