Surface: 15, 500 m²

Lab surface: 200 m²

Flagship technologies: 

• Monomers and polymers Heterocycles
• Polyphenol and azo dyes (with a low metal content)
• Photo-active compounds (PAC) / photo-active generators (PAG)
• Cyanine-based dyes
• NOVOLAK and phenolic resins
• Silicon chemistry (polysiloxane)
• Anthracene derivatives (microelectronic grade)

Last inspections: ISO 9001 February 2019

Certifications: 

• ISO 9001
• C-TPAT
• Responsible Care
• EcoVadis CSR Rating: Gold Certification

Number of scientists: 8

Surface: 50 000 m²

Lab surface: 750 m²

Capabilities: 35 KT PAP

Flagship technologies: Catalytical hydrogenation

Last inspection: June 2017

Certifications: 

• ISO 9001
• ISO 14001
• OHSAS 18001
• Certificate of GMP issued by Norwegian Medicines Agency for PAP workshop 2 only

Surface: 38, 619 m²

Lab surface: 560 m²

Capabilities:

• 8 KT of Paracetamol
• 4.5 KT of DC range

Flagship technologies: 

• Acetylation reaction
• Refining, granulation

Last inspections: 

• ANSM, January 2018
• NMPA ,August 2018

Certifications: 

• EU GMP
• ISO 140001
• OHSAS 18001
• EcoVadis CSR Rating: Silver Certification

Surface: 11, 678 m²

Lab surface: 695 m²

Capabilities: 

• 4 separate modules
• 72 m³ reactor capacity-
• 250 L – 6300 L vessels

Flagship technologies:

• Biphosphonate chemistry
• Hydrogenation (20 bar)
• Chlorination
• Cyanation (NaCN) in separate installations
• Reduction with complex hydrids
• Biocatalysis
• Manufacturing of parenteral/injectable APIs
• Separate production modules and final processing facilities

Last inspections:

• FDA 2019
• PMDA 2018
• FIMEA 2018

Number of scientists: 16

EcoVadis CSR Rating: Silver Certification

• Seqens Group headquarter
• Essential Drug Substances headquarter
• Solvent & Phenol Specialties headquarter
• Acid & Derivatives headquarter

Surface: 1, 000 m²

Lab surface: 500 m²

Capacities:

• 1 kilo-lab in fermentation (80 L total capacity)
• Robotic platform for highthroughput screening (HTS)
• Analytical platform for chromatography (GC, GC-MS, U-HPLC)

Flagship technologies: 

• Protein engineering
• Microbiology aerobic & anaerobic
• Syngas fermentation
• Enzymes & strains fermentation
• Biochemistry
• Biocatalysis
• Design of experiments (DoE)
• Data mining

Number of scientists: 19

EcoVadis CSR Rating: Silver Certification

Surface: 40, 000 m²

Lab surface: 2, 000 m²

Capabilities:

• 6 kilo-labs
• 2 cGMP pilot plants with 11 multipurpose reactors from 100 L to 2, 800 L (total capacity of 12 m³)
• Temperature range: -15/+150°C  (hastelloy reactor: -80/+200°C)
• 3 finishing rooms (agitated filter dryers, filters, dryers, milling and sieving equipments)

Flagship technologies:

• Crystallization expertise and technologiesd(salt, co-crystal and polymorph screenings, process development)
• Process Safety expertise and tecnologies
• Flow chemistry for fine chemicals
• Potent API process development
• Genotoxic Impurities
• Issue Management
• Generic A.P.I Solid state expertise

Last inspection: ANSM  October 2018

Certification: GMP

Number of scientists: 110

Other: Ecosystem Pharma with integrated services

Capabilities:

• 20 kt Salicylic ACid
• 6 kt Methyl Salicilate

Last inspections:

• ANSM, February 2018
• FDA, June 2016
• ISO, March 2018

Certifications:

• cGMP
• ISO 9001
• ISO 14001
• OHSAS 18001
• ISO 22000
• Kascher
• Halal
• EcoVadis CSR Rating: Platinium certification

Capabilities: 5, 050 L of reactors (100 L to 2, 000 )

Flagship technologies: Blood fractionation for In Vitro Diagnostic

Certifications:

• ISO 9001
• ISO 14001

Number of scientists: 2

Surface: 2, 000 m²

Lab surface: 70 m²

Capabilities: 4, 570 L of cosmetics reactors (80 L to 1 400 L)

Flagship technologies: Botanical extraction

Certifications: 

• ISO 9001
• ISO 14001
• ECOCERT/COSMOS

Number of scientists: 3

EcoVadis CSR Rating: Gold Certification 

Capabilities: 

• 65 m³ of reactors
• 100 L – 2 500 L vessels

EcoVadis CSR Rating: Gold Certification

Last inspections:

• ANSM 2019
• ANVISA (Brasil) 2018
• FDA 2016

Capabilities: 

• 70 m³ of GMP reactors
• 100 L – 8 000 L vessels

Flagship technologies: 

• Optical resolution
• Enzymatic hydrolysis
• Enantioselective reduction
• Low-temperature reactions (-80 °C)
• Specific reduction
• Hydrogenation (40 bar)
• Organomagnesium compounds
• Thin-layer distillation

EcoVadis CSR Rating: Gold Certification 2019

Last inspections:

• FDA 2018
• ANSM 2019

Flagship technologies: Distillation

EcoVadis CSR Rating: Gold Certification

Capabilities: 

• 100 m³ of GMP reactors
• 50 L – 10 000 L vessels

Flagship technologies: 

• Organometallic chemistry
• Large-scale hydrogenation
• Diborane chemistry
• Ethylene oxide reactions
• Biocatalysis platform
• Polymer production (PLGA)
• Enzymatic synthesis Skraup reactions

EcoVadis CSR Rating: Silver certification

Last inspections:

• FDA 2018
• ANSM 2021

Surface: 59, 000 m²

Flagship technologies: Propylen underground storage

Certifications:

• ISO 9001
• ISO 14001
• ISO 50001
• OHSAS 18001

Capabilities: 

• 5, 500 (storage) tons of Hydrochloric Acid
• 60 kt (production) of Ferric Chloride
• 13 kt of Alpha-Methylstyrene
• 2 kt of Acetophenone
• 8 kt of Isopropanol

Certifications: 

• ISO 9001
• ISO 14001
• OHSAS 18001
• EcoVadis CSR Rating: Platinum certification

Surface : 160 000 m²

Capabilities: 

• 185 kT Phenol
• 70 kT Isopropanol
• 27 kT Acétate Isopropyle
• 5 kT DIPE

Certifications: 

• ISO 9001
• ISO 14001
• ISO 50001
• OSHAS 18001

EcoVadis CSR Rating Platinum medal

Capabilities: 6 KT of Acetylsalicylic Acid

Certifications:

• cGMP
• ISO 9001
• ISO 14001
• OHSAS 18001

EcoVadis CSR Rating: Platinum Certification

Surface: 120, 000 m²

Capabilities: 190 m³ of ISO 9001 reactors and kilo-lab

Flagship technologies: Most standard organic synthesis reactions (large volumes)

Certifications:

• ISO 9001
• EcoVadis CSR Rating: Gold Certification

Surface: 48, 000 m²

Lab surface: 700 m²

Capabilities:

• Total reactor capacity: 92 m³
• Reaction vessels: 1 to 6 300 L; temperature  -80°C to +250 °C
• Multi-purpose state of the art cGMP facilty: 4 independent, vertical integrated production trains 800 L train, 2 x 3 000 L trains plus 1 x 3 000 L low temperature hydrogenation reactor and 6 000 L train
• Classic two-floor layout Facility: 20 vessels with capacity between 800 and 6 000 L (glaslined and SS)
• Autoclaves (operational range up to 100 bar)
• Kilo-Lab: 3 reactors: 25 / 100 / 250 L

Flagship technologies:

• Hydrogenation
• Reductive amination
• Organometallic reactions
• Protected AADs (Aminoacid derivatives)
• Carbonylation & Hydroformylation
• Pressure aminolysis, other reactions under pressure
• Cryogenic chemistry
• Enantiopure synthesis
• Cyanation high volumes (NaCN) C-C coupling
• Reductions
• Halogenation

Number of scientists: 25

Last inspections:

• FDA 2018
• The last inspection by the authorities took place on the 23^rd November 2021 / Die letzte Inspektion der Aufsichtsbehörde fand am 23.11.2021 statt.

Certifications:

• GMP
• ISO 9001
• ISO 50001

Seveso regulation – Information for the public / Störfallverordnung – Information der Öffentlichkeit

EcoVadis CSR Rating: Gold Certification

Lab surface: 500 sqm

Flagship technologies:

• Complex chemistry
• Enzymatic Process Development
• Solid State (Polymorphism Research / Salts / Co-Crystals)

Number of Scientists: 33

Surface: 2,264m²

Website : Welcome (vanamaliorganics.com)

Certifications:

• ISO 9001-2015
• GMP

Flagship Technologies:

• Cryogenic reactions (-70 °C to -85 °C)
  Thermal rearrangements/thermal cyclizations
• Reductions / Brominations / nitrations/ sulphonations
• Cyclic amidations
• Dihydroxylations
• Chiral chemistry
• Optical resolutions

Capabilities:

• Total multi-purpose reactor volume 35 Reactors
• Total multi-purpose reactor volume 53,010 L
• Range of reactor volumes 50-4000 L (Stainless Steel, Glass-Lined, High Vacuum distillations, Hydrogenation 20 bar)

Lab surface: 3000 sqm

Capabilities:

• Number of Reactors 54
• Total multi-purpose reactor volume 110,000 L
• Wide range of reactor volumes 10-12,000 L (Stainless Steel, Hastelloy, Glass-Lined, Hydrogenation 50 bar)

Flagship Technologies:

• Enzymatic Process Development
• Solid State (Polymorphism Research / Salts / Co-Crystals)
• Particle Design
• Spray Drying & Bioavailability Enhancing

Highly Potent containment capabilities including micronization up to OEL<1µg/m3

Last inspections:

• Israeli Ministry Of Health in January 2019
• US FDA in July 2018

Number of Scientists: 42

Surface: 24, 000 m²

Lab surface: 100 m²

Capabilities: 3.5 KT ASA

Flagship technologies: 

• Continuous Acetylsalicylic
• Acid Production Recycled
• Salicyclic Acid (Industrial-grade)

Last inspections: 

• USFDA, March 2018
• TFDA, May 2018

Certifications: 

• ISO 9001
• ISO 14001
• OHSAS 18001
• EcoVadis CSR Rating: Gold Certification 

Number of scientists: 11

Surface: 42, 000 m²

Capabilities:

• 4 reaction vessels (316 L and Duplex 2205) of 25-35 m³ capacity with associated distillation columns of 6-30 plates
• Glass lined reaction vessel (14 m³)

Flagship technologies:

 Primary Reactions

• Esterification
• Etherification
• Epoxidation
• Methylation/Methyl chloride capping
• Quaternisation
• Transeterification.

Secondary reactions

• Acetal formation
• Acetylation
• Aldol condensation,
• Alkylation
• Diels-Alder
• Hydrolysis
• Isomerisation
• Oxidation
• Polymerisation

Solvent Recovery

• Alcohols,
• Amines
• Aromatic solvents
• Esters
• Glycols
• Ketones
• Organic acids

Certifications:

• ISO 9001
• ISO 14001
• EcoVadis CSR Rating: Gold Certification

Surface: 68, 000 m²

Capabilities:

• 48 plate distillation column
• 18 plate distillation column
• 4 reaction vessels (316 L and Duplex 2205) of 25-30m³ capacity with distillation columns attached (6-30 plates)

Flagship technologies:

 Primary Reactions

• Esterification
• Etherification
• Epoxidation
• Methylation/Methyl chloride capping
• Quaternisation
• Transesterification.

Secondary reactions

• Acetal formation
• Acetylation
• Aldol condensation,
• Alkylation
• Diels-Alder
• Hydrolysis
• Isomerisation
• Oxidation
• Polymerisation

Solvent Recovery

• Alcohols,
• Amines
• Aromatic solvents
• Esters
• Glycols
• Ketones
• Organic acids

Certifications: 

• ISO 9001
• ISO 14001
• EcoVadis CSR Rating: Gold Certification

Facility Highlights:

• 10,000 sq. ft. facility with 6 laboratories that house 28 hoods.
• 30 person staff, ¾ PhD’s
• 5 kilo lab hoods

Equipment:

• Glassware from ml to 100 liter jacketed glass vessels
• 20 and 50 liter rotovaps
• Various filtration equipment
• Temperature ranges -78 – 240°C
• Thin film evaporation
• Flash chromatography
• Prep chromatography
• Micronization
• High pressure par reactors

Lab surface: 460 m²

Manufacturing capabilities:

• Class 100,000 GMP kilo suites for Phase 1 and small scale cGMP manufacturing
• Pilot plant (50gal-200gal)
• Production plant (500-2000gal)
• Temperature capability of -50 to 225ºC
• Hastelloy, Glass, and Stainless vessels

Filtration/Drying

• Centrifuge
• Hastelloy and Glass Filter/Dryers
• Qualified USP Purified water system

Last inspection: July 2018 FDA Inspection

EcoVadis CSR Rating: Silver Certification