Advanced Specialties Canada
CanadaQC J3B8J8Saint-Jean-sur-Richelieu
Surface: 15, 500 m²
Lab surface: 200 m²
Flagship technologies:
- Monomers and polymers Heterocycles
- Polyphenol and azo dyes (with a low metal content)
- Photo-active compounds (PAC) / photo-active generators (PAG)
- Cyanine-based dyes
- NOVOLAK and phenolic resins
- Silicon chemistry (polysiloxane)
- Anthracene derivatives (microelectronic grade)
Last inspections: ISO 9001 February 2019
Certifications:
- ISO 9001
- C-TPAT
- Responsible Care
- EcoVadis CSR Rating: Gold Certification
Number of scientists: 8
Shanghai
China200060 Shanghai
Consumer Healthcare Yangzi
China225404 Taizhou
Surface: 50 000 m²
Lab surface: 750 m²
Capabilities: 35 KT PAP
Flagship technologies: Catalytical hydrogenation
Last inspection: June 2017
Certifications:
- ISO 9001
- ISO 14001
- OHSAS 18001
- Certificate of GMP issued by Norwegian Medicines Agency for PAP workshop 2 only
Consumer Healthcare Wuxi
China214185Wuxi
Surface: 38, 619 m²
Lab surface: 560 m²
Capabilities:
- 8 KT of Paracetamol
- 4.5 KT of DC range
Flagship technologies:
- Acetylation reaction
- Refining, granulation
Last inspections:
- ANSM, January 2018
- NMPA ,August 2018
Certifications:
- EU GMP
- ISO 140001
- OHSAS 18001
- EcoVadis CSR Rating: Silver Certification
Consumer Healthcare Hong Kong
ChinaHong Kong
CDMO Turku
Finland20210 Turku
Surface: 11, 678 m²
Lab surface: 695 m²
Capabilities:
- 4 separate modules
- 72 m³ reactor capacity-
- 250 L – 6300 L vessels
Flagship technologies:
- Biphosphonate chemistry
- Hydrogenation (20 bar)
- Chlorination
- Cyanation (NaCN) in separate installations
- Reduction with complex hydrids
- Biocatalysis
- Manufacturing of parenteral/injectable APIs
- Separate production modules and final processing facilities
Last inspections:
- FDA 2019
- PMDA 2018
- FIMEA 2018
Number of scientists: 16
EcoVadis CSR Rating: Silver Certification
Ecully
France69134Ecully
- Seqens Group headquarter
- Essential Drug Substances headquarter
- Solvent & Phenol Specialties headquarter
- Acid & Derivatives headquarter
Nîmes Protéus by Seqens
France30000 Nîmes
Surface: 1, 000 m²
Lab surface: 500 m²
Capacities:
- 1 kilo-lab in fermentation (80 L total capacity)
- Robotic platform for highthroughput screening (HTS)
- Analytical platform for chromatography (GC, GC-MS, U-HPLC)
Flagship technologies:
- Protein engineering
- Microbiology aerobic & anaerobic
- Syngas fermentation
- Enzymes & strains fermentation
- Biochemistry
- Biocatalysis
- Design of experiments (DoE)
- Data mining
Number of scientists: 19
EcoVadis CSR Rating: Silver Certification
Porcheville (Seqens'Lab)
France78440 Porcheville
Surface: 40, 000 m²
Lab surface: 2, 000 m²
Capabilities:
- 6 kilo-labs
- 2 cGMP pilot plants with 11 multipurpose reactors from 100 L to 2, 800 L (total capacity of 12 m³)
- Temperature range: -15/+150°C (hastelloy reactor: -80/+200°C)
- 3 finishing rooms (agitated filter dryers, filters, dryers, milling and sieving equipments)
Flagship technologies:
- Crystallization expertise and technologiesd(salt, co-crystal and polymorph screenings, process development)
- Process Safety expertise and tecnologies
- Flow chemistry for fine chemicals
- Potent API process development
- Genotoxic Impurities
- Issue Management
- Generic A.P.I Solid state expertise
Last inspection: ANSM October 2018
Certification: GMP
Number of scientists: 110
Other: Ecosystem Pharma with integrated services
Consumer Healthcare Roussillon
France38556 Roussillon
Capabilities:
- 20 kt Salicylic ACid
- 6 kt Methyl Salicilate
Last inspections:
- ANSM, February 2018
- FDA, June 2016
- ISO, March 2018
Certifications:
- cGMP
- ISO 9001
- ISO 14001
- OHSAS 18001
- ISO 22000
- Kascher
- Halal
- EcoVadis CSR Rating: Platinium certification
In Vitro Diagnostic Limoges
France87068 Limoges
Capabilities: 5, 050 L of reactors (100 L to 2, 000 )
Flagship technologies: Blood fractionation for In Vitro Diagnostic
Certifications:
- ISO 9001
- ISO 14001
Number of scientists: 2
Cosmetics Limoges
France87068 Limoges
Surface: 2, 000 m²
Lab surface: 70 m²
Capabilities: 4, 570 L of cosmetics reactors (80 L to 1 400 L)
Flagship technologies: Botanical extraction
Certifications:
- ISO 9001
- ISO 14001
- ECOCERT/COSMOS
Number of scientists: 3
EcoVadis CSR Rating: Gold Certification
CDMO Villeneuve-la-Garenne
France92390 Villeneuve-la-Garenne
Capabilities:
- 65 m³ of reactors
- 100 L – 2 500 L vessels
EcoVadis CSR Rating: Gold Certification
Last inspections:
- ANSM 2019
- ANVISA (Brasil) 2018
- FDA 2016
CDMO Limay
France78520Limay
Capabilities:
- 70 m³ of GMP reactors
- 100 L – 8 000 L vessels
Flagship technologies:
- Optical resolution
- Enzymatic hydrolysis
- Enantioselective reduction
- Low-temperature reactions (-80 °C)
- Specific reduction
- Hydrogenation (40 bar)
- Organomagnesium compounds
- Thin-layer distillation
EcoVadis CSR Rating: Gold Certification 2019
Last inspections:
- FDA 2018
- ANSM 2019
CDMO Bourgoin-Jallieu
France38300 Bourgoin-Jallieu
Flagship technologies: Distillation
EcoVadis CSR Rating: Gold Certification
CDMO Aramon
France30390Aramon
Capabilities:
- 100 m³ of GMP reactors
- 50 L – 10 000 L vessels
Flagship technologies:
- Organometallic chemistry
- Large-scale hydrogenation
- Diborane chemistry
- Ethylene oxide reactions
- Biocatalysis platform
- Polymer production (PLGA)
- Enzymatic synthesis Skraup reactions
EcoVadis CSR Rating: Silver certification
Last inspections:
- FDA 2018
- ANSM 2021
Solvent & Phenol Specialties Grand-Serre
France26530Le Grand-Serre
Surface: 59, 000 m²
Flagship technologies: Propylen underground storage
Certifications:
- ISO 9001
- ISO 14001
- ISO 50001
- OHSAS 18001
Acid & Derivatives Pont-de-Claix
France38800Le Pont-de-Claix
Capabilities:
- 5, 500 (storage) tons of Hydrochloric Acid
- 60 kt (production) of Ferric Chloride
- 13 kt of Alpha-Methylstyrene
- 2 kt of Acetophenone
- 8 kt of Isopropanol
Certifications:
- ISO 9001
- ISO 14001
- OHSAS 18001
- EcoVadis CSR Rating: Platinum certification
Solvent & Phenol Specialties Roussillon
France38556 Roussillon
Surface : 160 000 m²
Capabilities:
- 185 kT Phenol
- 70 kT Isopropanol
- 27 kT Acétate Isopropyle
- 5 kT DIPE
Certifications:
- ISO 9001
- ISO 14001
- ISO 50001
- OSHAS 18001
EcoVadis CSR Rating Platinum medal
Consumer Healthcare Saint-Fons
France69190Saint-Fons
Capabilities: 6 KT of Acetylsalicylic Acid
Certifications:
- cGMP
- ISO 9001
- ISO 14001
- OHSAS 18001
EcoVadis CSR Rating: Platinum Certification
Advanced Specialties Couterne
France61410Couterne
Surface: 120, 000 m²
Capabilities: 190 m³ of ISO 9001 reactors and kilo-lab
Flagship technologies: Most standard organic synthesis reactions (large volumes)
Certifications:
- ISO 9001
- EcoVadis CSR Rating: Gold Certification
Massy
France91300Massy
CDMO Lahr
Germany77933 Lahr
Surface: 48, 000 m²
Lab surface: 700 m²
Capabilities:
- Total reactor capacity: 92 m³
- Reaction vessels: 1 to 6 300 L; temperature -80°C to +250 °C
- Multi-purpose state of the art cGMP facilty: 4 independent, vertical integrated production trains 800 L train, 2 x 3 000 L trains plus 1 x 3 000 L low temperature hydrogenation reactor and 6 000 L train
- Classic two-floor layout Facility: 20 vessels with capacity between 800 and 6 000 L (glaslined and SS)
- Autoclaves (operational range up to 100 bar)
- Kilo-Lab: 3 reactors: 25 / 100 / 250 L
Flagship technologies:
- Hydrogenation
- Reductive amination
- Organometallic reactions
- Protected AADs (Aminoacid derivatives)
- Carbonylation & Hydroformylation
- Pressure aminolysis, other reactions under pressure
- Cryogenic chemistry
- Enantiopure synthesis
- Cyanation high volumes (NaCN) C-C coupling
- Reductions
- Halogenation
Number of scientists: 25
Last inspections:
- FDA 2018
- The last inspection by the authorities took place on the 23rd November 2021 / Die letzte Inspektion der Aufsichtsbehörde fand am 23.11.2021 statt.
Certifications:
- GMP
- ISO 9001
- ISO 50001
Seveso regulation – Information for the public / Störfallverordnung – Information der Öffentlichkeit
EcoVadis CSR Rating: Gold Certification
CDMO Frankfurt
Germany60549Frankfurt
Pune
India411004Pune
Lab surface: 500 sqm
Flagship technologies:
- Complex chemistry
- Enzymatic Process Development
- Solid State (Polymorphism Research / Salts / Co-Crystals)
Number of Scientists: 33
Hyderabad (Vanamali)
IndiaHyderabad
Surface: 2,264m²
Website : Welcome (vanamaliorganics.com)
Certifications:
- ISO 9001-2015
- GMP
Flagship Technologies:
- Cryogenic reactions (-70 °C to -85 °C)
Thermal rearrangements/thermal cyclizations - Reductions / Brominations / nitrations/ sulphonations
- Cyclic amidations
- Dihydroxylations
- Chiral chemistry
- Optical resolutions
Capabilities:
- Total multi-purpose reactor volume 35 Reactors
- Total multi-purpose reactor volume 53,010 L
- Range of reactor volumes 50-4000 L (Stainless Steel, Glass-Lined, High Vacuum distillations, Hydrogenation 20 bar)
Neot Hovav
Israel8413502Beer Sheva
Lab surface: 3000 sqm
Capabilities:
- Number of Reactors 54
- Total multi-purpose reactor volume 110,000 L
- Wide range of reactor volumes 10-12,000 L (Stainless Steel, Hastelloy, Glass-Lined, Hydrogenation 50 bar)
Flagship Technologies:
- Enzymatic Process Development
- Solid State (Polymorphism Research / Salts / Co-Crystals)
- Particle Design
- Spray Drying & Bioavailability Enhancing
Highly Potent containment capabilities including micronization up to OEL<1µg/m3
Last inspections:
- Israeli Ministry Of Health in January 2019
- US FDA in July 2018
Number of Scientists: 42
Consumer Healthcare Bangpoo
Thailand10280 Samut Prakan
Surface: 24, 000 m²
Lab surface: 100 m²
Capabilities: 3.5 KT ASA
Flagship technologies:
- Continuous Acetylsalicylic
- Acid Production Recycled
- Salicyclic Acid (Industrial-grade)
Last inspections:
- USFDA, March 2018
- TFDA, May 2018
Certifications:
- ISO 9001
- ISO 14001
- OHSAS 18001
- EcoVadis CSR Rating: Gold Certification
Number of scientists: 11
Custom Specialties Billingham
United KingdomTS23 1PY Billingham
Surface: 42, 000 m²
Capabilities:
- 4 reaction vessels (316 L and Duplex 2205) of 25-35 m³ capacity with associated distillation columns of 6-30 plates
- Glass lined reaction vessel (14 m³)
Flagship technologies:
Primary Reactions
- Esterification
- Etherification
- Epoxidation
- Methylation/Methyl chloride capping
- Quaternisation
- Transeterification.
Secondary reactions
- Acetal formation
- Acetylation
- Aldol condensation,
- Alkylation
- Diels-Alder
- Hydrolysis
- Isomerisation
- Oxidation
- Polymerisation
Solvent Recovery
- Alcohols,
- Amines
- Aromatic solvents
- Esters
- Glycols
- Ketones
- Organic acids
Certifications:
- ISO 9001
- ISO 14001
- EcoVadis CSR Rating: Gold Certification
Custom Specialties Middlesbrough
United KingdomTS3 6AF Middlesbrough
Surface: 68, 000 m²
Capabilities:
- 48 plate distillation column
- 18 plate distillation column
- 4 reaction vessels (316 L and Duplex 2205) of 25-30m³ capacity with distillation columns attached (6-30 plates)
Flagship technologies:
Primary Reactions
- Esterification
- Etherification
- Epoxidation
- Methylation/Methyl chloride capping
- Quaternisation
- Transesterification.
Secondary reactions
- Acetal formation
- Acetylation
- Aldol condensation,
- Alkylation
- Diels-Alder
- Hydrolysis
- Isomerisation
- Oxidation
- Polymerisation
Solvent Recovery
- Alcohols,
- Amines
- Aromatic solvents
- Esters
- Glycols
- Ketones
- Organic acids
Certifications:
- ISO 9001
- ISO 14001
- EcoVadis CSR Rating: Gold Certification
Boston'Lab (Devens)
United StatesMA 01434Devens
Facility Highlights:
- 10,000 sq. ft. facility with 6 laboratories that house 28 hoods.
- 30 person staff, ¾ PhD’s
- 5 kilo lab hoods
Equipment:
- Glassware from ml to 100 liter jacketed glass vessels
- 20 and 50 liter rotovaps
- Various filtration equipment
- Temperature ranges -78 – 240°C
- Thin film evaporation
- Flash chromatography
- Prep chromatography
- Micronization
- High pressure par reactors
CDMO Newburyport
United StatesMA 01950Newburyport
In 2005, PCI expanded its manufacturing facilities by acquiring its current site in Newburyport, Massachusetts. The facility had its most recent successful cGMP inspection by the FDA in April 2015.
Surface: 5, 600 m²
Total capacity : 20,000 gal
Lab surface: 460 m²
Manufacturing capabilities:
- Class 100,000 GMP kilo suites for Phase 1 and small scale cGMP manufacturing
- Pilot plant (50gal-200gal)
- Production plant (500-2000gal)
- Temperature capability of -50 to 225ºC
- Hastelloy, Glass, and Stainless vessels
Filtration/Drying
- Centrifuge
- Hastelloy and Glass Filter/Dryers
- Qualified USP Purified water system
Last inspection: July 2018 FDA Inspection
EcoVadis CSR Rating: Silver Certification
CDMO Newburyport
United StatesMA 01950Newburyport
Custom Manufacturing: don.laferle@seqens.com
Proprietary API: laurent.alexandre@seqens.com
Consumer Healthcare Robbinsville
United StatesNJ 08691Robbinsville